Wade Wilson was a thug that had been a soldier of US Special Forces. One day fell in love with Vanessa (a prostitute). When his life seem that was good he was diagnosed with a terminal cancer. To save his life he was subjected to "Weapon X": a risky experiment that causes a genetic alteration in your body. After undergoing this complicated experiment, the face and body are horribly disfigured, but he acquired a big regeneration and abilities higher than the humans. For this reason decide to kill the person that did the experiment and his team. Deadpool attacked the convoy of cars Francis (the leader of the organization), demanding a cure for his disfigurement. The fight is suddenly interrupted by Colossus and Negasonic, that want that Deadpool join in the X-Men. Deadpool discovers that Vanessa has been kidnapped by Francis.
Deadpool decides to go against Francis with the help of Coloso and Negasonic and finally he is defeat and Wade obligate him to return his previous appearance, but Francis says that he really can't do that, Deadpool decides to kill him. Vanessa confronts Wade who apologizes for his escape, but Wade says that his appearance isn't the same and has the fears that Vanessa doesn't accept it, but finally they bring back together.
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